Long Term T1D's With Good Diabetes Health
Monday, October 12, 2020
Wednesday, August 12, 2020
I received my Joslin 75 year medal yesterday, August 10. I will not complete 75 years of Type 1 until September 15, so I have received the medal early. Several days ago I mailed a copy of my book to Joslin. It gave a thorough description of the days leading up to my diagnosis in 1945. I think the book may have given the needed proof for my 75 years.
Dr. King, Director of Research and Founder of the 50-Year Medalist Study sent me this message:
"We honor those with long duration type 1 diabetes by hosting a Medalist gathering every other year. The next celebration will be in 2021. I hope to have the opportunity to meet and personally honor you at this meeting."
Saturday, May 30, 2020
Thursday, May 28, 2020
Friday, May 22, 2020
Thursday, May 14, 2020
C-peptide was discovered in 1967. The first actual use of a C-peptide test was in 1972. In more recent times, C-peptide has been found to have an effect on microvascular blood flow and tissue health.
Type I diabetics typically have very low levels of C-peptide because most of their beta cells have been destroyed. This has been seen in the development of long-term complications such as peripheral and autonomic neuropathy. I have experienced both kinds of neuropathies, but neither type has proved to be particularly problematic after 74 years of type 1.
C-peptide has been shown to significantly improve nerve and kidney function. It has also been reported to have anti inflammatory effects as well as aid repair of smooth muscle cells.
When experimenting with type 1 diabetics who lacked sufficient C-peptide, improvements were seen on diabetic peripheral neuropathy, nephropathy and other complications associated with long-term type I diabetes. Dosing with C-peptide was shown to be safe and there were no effects of C-peptide demonstrated.
The quotes given below were found in my online research:
"Newly diagnosed diabetes patients often get their C-peptide levels measured as a means of distinguishing between type 1 diabetes, Maturity Onset Diabetes of the Young (MODY), Latent Autoimmune Diabetes of Adults (LADA) and type 2 diabetes."
"The pancreas of a type 1 diabetic does not usually produce adequate insulin, so a decreased level of C-peptide is expected. Some secretion can still be present during the honeymoon stage for type 1 diabetics.
C-peptide levels in type 2 diabetics are normal, or even higher than normal. Determining the amount of C-peptide in people who inject or pump synthetic insulin can help to determine how much of their own natural insulin these patients are still producing, or if they produce any at all."
"The results of a C-Peptide test can vary from lab to lab. So different labs may have different 'normal' ranges. Doctors will sometimes evaluate your results based on your health and other factors. A C-Peptide value that falls outside the normal range may still be normal for you. The C-Peptide and blood glucose levels are measured at the same time to give a better evaluation.
A normal C-peptide level may be indicated as – Fasting: 0.51-2.72 nanograms per milliliter (ng/mL) or 0.17-0.90 nanomoles per liter (nmol/L)"
The first 725+ participants in the Joslin Medalist Study (2005-2015) were tested for their C-peptide levels. That test along with a glucose tolerance test showed that more than 66% of these long term diabetics did still produce some of their own insulin. My C-peptide level was less than 0.1, showing that my good health after 74 years of diabetes has to be explained by factors other than insulin secretion.
"Persons with LADA typically have low, although sometimes moderate, levels of C-peptide as the disease progresses and high blood glucose levels. The most common MODY syndrome may also have normal fasting C-peptide results because the flaw in this case is in the secretion of insulin in response to rising glucose and fasting secretion is still near normal.
Their postprandial C-peptide however is below normal with elevated blood glucose.
Low levels of both C-peptide and blood glucose are found in liver disease, a severe infection, Addison’s disease, or insulin therapy."
I have believed for several years that C-Peptide present in the animal insulins I used for 50 years may have protected me against certain complications. It may help explain the longevity and good health of most of the Joslin Medalists. Today's synthetic insulins do not contain any C-peptide. I have experienced several minor complications since starting synthetic insulins, but none of them have been particularly problematic. I asked Dr. King, head of the Joslin Medalist Study, about this. He said he does not think that C-peptide is a factor in explaining the longevity and good health of the medalists. Maybe he will have changed his mind as the research continues.
The link below is one of my references.
There was an attempt by a company called Cebix to produce an injectable form of C-peptide. The project failed during human trials. Here is some of the background of that project.
There does not seem to be any present day attempts being made to add C-peptide to insulin, and the attempt to produce an injectable form of C-peptide has failed. I am not aware that any other attempts are being made to provide us with C-peptide, but I have not given up hope. I am thinking that each individual could be tested and the appropriate amount of C-peptide needed could be determined. Then a prescription could be given that would enable that individual to inject that amount of C-peptide daily, weekly, or for an appropriate time schedule. That may seem far fetched, but I think there has to be a way for us to receive some of this potentially valuable substance.
What are your thoughts?
Wednesday, May 6, 2020
Saturday, May 2, 2020
Friday, April 24, 2020
Saturday, April 18, 2020
Friday, April 3, 2020
Thursday, March 26, 2020
Saturday, March 21, 2020
Tuesday, March 17, 2020
Friday, March 6, 2020
Wednesday, March 4, 2020
Tuesday, March 3, 2020
Wednesday, February 26, 2020
Throughout my early years as a diabetic I had no major health problems, and I coasted along rather easily. I was always very skinny, maybe slightly underweight, until many years later. I had high urine sugar every day, and usually at night. There were, however, some nights that I had very bad hypos. My bedroom door was always left open at night, and my room was immediately across the hall from my parent's room. Mother was keyed in to my thrashing about, and the moans I would make when having a hypo. She would jump out of bed, and grab the glass containing several tablespoons of sugar. She stopped at the bathroom, partially filled the glass with water, stirred the mixture with a spoon, and entered my room. Daddy raised my body, sat on the bed behind me, and held me while Mother slowly poured the sugar water into my mouth. That usually worked very well, but occasionally my mouth was shut so tightly that she could not get any of the liquid into my mouth. Some of these hypos were very bad, and they became seizures. It took a long time to get me to the stage that they could get me to drink some of the sugar water. She would rub some of the liquid on my lips, and I would lick my lips. This gave me just enough sugar so I would start to relax, and then she could get me to swallow some of the sugar water. I would come out of these hypos, not remembering any part of what had happened. Mother gave me all the details the next morning, and again when I was preparing to write my book. I was always so grateful that they took such good care of me at those times. I have no idea how many of those seizures I had before I was an adult, but I know there were many of them. If we had meters for testing, basal and bolus insulin, and carb counting, things would have been very different. There may have been less serious hypos, without the terrible lows that caused seizures. The animal insulin I used for my first 50 years was neither bolus nor basal. It worked at the same level all day, and all night. I think that level was too much at night, and that was probably the reason I had low blood sugar so many times while I was sleeping. That insulin was a 24 hour insulin, with only one injection each day. There was no way of having different dosages with different levels at different times of the day.
To prevent hypos at school, I was not permitted to play with the other kids during play periods or gym. It was that way in grades 1-12. I played at home with a neighborhood friend, but Mother kept a close watch on me. I was usually able to feel my lows before they were so bad. I would tell Mother, and she would give me some sugar. I carried a small container of sugar with me while in schooI. I was never given candy. I think my parents did not want me to know the taste of candy, and other sugar sweetened things. There was never any ice cream in the house, and I assumed there was never any candy, but several years ago my sister told me an interesting story. When we shopped at our grocery store, no candy was purchased. Daddy stopped on his way home from work in the late evening, and bought candy. It was stored very high in a kitchen cabinet. I never saw it. My sister was given a candy bar, and she would eat it in the kitchen. If I entered the kitchen while she was eating candy, she would hide the candy behind her back, with her back against a wall. I never became suspicious. She waited more than 50 years to tell me that. I'm glad she got to have candy, and I am glad I never tasted it. There was artificially sweetened candy that we bought back then. I think the companies selling the candy were Diamel, Loeb and Estee. It wasn't so bad, I still remember the taste. Sweet story, sweet sister, sweet candy. HA!
When I had just started eighth grade I had intestinal flu. I stayed at home several days, and I could not keep anything in my stomach, not the medicine the doctor had prescribed, not even water. My parents thought that since I was not eating then they should not give me insulin. They were afraid I would have a hypo. They did not check this out with the doctor. After several days of no food, no water, no medicine and no insulin I was so weak I could not lift my arms, and I was barely able to move my head. I think I must have DKA at the time. The doctor came to our house, and called an ambulance. I stayed in the hospital almost two weeks. I recovered very well, and returned to school. I hope that those of you reading this know that you need your insulin even if you are not eating. You still need your "basal" insulin under these conditions, but you do not need your "bolus" insulin if you are not eating.
After Anita and I were married in 1964, I was still using the animal insulin. My control was better, with fewer lows, but there were some nights that I had bad hypos, and a few seizures. Anita learned how to handle those lows, and she did a wonderful job. In the 1980's she had to call the local paramedics. That happened three times, and I was given injections of glucagon. The first time I was taken to the hospital, but not the other two times. After the injections I was immediately able to stand up and walk around. It is amazing how fast glucagon can work. On the other two occasions the paramedics let me sign a form that gave me permission to stay home, and avoid going to the hospital.
In the 1990's I started using Humalog, and carb counting. I had a meter for testing my blood sugar at home. My control improved so much! In 2007 I started using an insulin pump, and my control improved even more. I stopped having very low blood sugar. The lows I was having then were not bad enough for me to need any assistance. Anita, however, has memories of how it used to be. She watches me like she did back then. She cannot sleep well unless I tell her my blood sugar level at 1, 4, and 7 AM. That disturbed my sleep a lot for many years, while having to do a finger stick three times during the night. It was difficult to fall back to sleep some of those times. It is so much easier now with my CGM. I can look at the CGM, give her the number, and then go back to sleep. No problem!
I have never been upset with Anita for having me do those night checks. She had to put up with so many hypos at night in the first four decades of our marriage, and she never complained. She never showed any signs of panic, or aggravation with my lows back then. She may have saved my life on some occasions. I love her so much for doing her job, and doing it well. She has painful memories of how it used to be, and my giving her my numbers during the night is the least I can do for her. I will never complain. Never!!
Saturday, February 22, 2020
Sunday, February 16, 2020
Saturday, February 15, 2020
Tuesday, February 11, 2020
" Dizziness and fainting upon standing caused by a drop in blood pressure.
Urinary problems, including difficulty starting urination, urinary
incontinence and an inability to completely empty your bladder, which can lead to urinary tract infections.
Sexual difficulties, including problems achieving or maintaining an
erection (erectile dysfunction) or ejaculation problems in men, and
vaginal dryness and difficulties with arousal and orgasm in women.
Difficulty digesting food, due to abnormal digestive function and slow
emptying of the stomach (gastroparesis). This can cause a feeling of
fullness after eating little, loss of appetite, diarrhea,
constipation, abdominal bloating, nausea, vomiting, difficulty
swallowing and heartburn.
Sweating abnormalities, such as excessive or decreased sweating, which affects the ability to regulate body temperature.
Sluggish pupil reaction, making it difficult to adjust from light to
dark and causing problems with driving at night.
Exercise intolerance, which may occur if your heart rate remains
unchanged instead of appropriately increasing and decreasing in
response to your activity level."
My neurologist diagnosed my AN in 2010 after I had mentioned extreme dizziness in the AM, and my occasionally falling down. My BP was dropping as much as 40 points when standing up in the morning. Cutting my BP med to half doses has helped, but my BP is still irregular in the morning. I have four of the seven symptoms listed, and they are gradually becoming more pronounced. Gastroparesis is one of the symptoms, but I do not have that problem at the present time. I hope I never do.
Do you have AN, or do you think you do?