Thursday, May 11, 2017

C-peptide...Part 2

C-peptide .....Part 2

In the 1970s a study seemed to show that C-peptide was of no practical value in preventing diabetes complications, but "...the possibility that C-peptide may exert direct effects of its own was reevaluated in the early 1990s. A series of studies was undertaken involving administration of the peptide to patients with type 1 diabetes, who lack C-peptide. This approach gave positive results, and it became apparent that replacement of C-peptide in physiological concentrations results in significant improvements in several diabetes-induced functional abnormalities. These surprising findings prompted a renewed interest in C-peptide physiology, and during the following 15 years, a steadily increasing number of reports on new aspects of C-peptide physiology emerged. The information available included studies of the peptide’s interaction with cell membranes and its intracellular signaling properties. In vivo studies in animal models of type 1 diabetes have defined a beneficial influence of C-peptide on diabetes-induced functional and structural abnormalities of the kidney, peripheral nerves, and central nervous system. In addition, several studies in type 1 diabetic patients describing positive effects of C-peptide replacement therapy on nerve and kidney function have appeared. The wealth of information now available supports the notion that C-peptide administration, together with regular insulin therapy, may be beneficial in the prevention and treatment of microvascular complications."

Here is the link with a more thorough presentation of that research:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314360/

There have been many online discussions concerning C-peptide, and its being potentially helpful to people with type 1 diabetes.The following are examples of those discussions.

Here is a link giving a good discussion about C-peptide on diabetesdaily.com. I have been an active member there since 2007. (I don't know if you can view this discussion unless you are a member of Diabetes Daily.)

https://www.diabetesdaily.com/forum/diabetes-news-and-studies/79493-low-c-peptide-bad-type-1-a-2

There was an attempt by a company called Cebix to produce an injectable form of C-peptide. The project failed during human trials. Here is some of the background of that project.

http://www.xconomy.com/san-diego/2015/02/23/cebix-shuts-down-following-mid-stage-trial-of-c-peptide-drug/#

In another online diabetes support group, one person posted that Lilly had experimented in including C-peptide in the human insulin they had been producing. I do not have any details on this, and have not been able to find any information by researching online. If anyone finds any information about that, please let me know. Lilly aborted the experiment, so I am told.

Another discussion was made that suggested that having C-peptide in the synthetic insulin that we use today could cause major problems. People with type 2 still produce a significant amount of their own insulin. That insulin contains C-peptide. If type 2 individuals then injected insulin with C-peptide, there might be an overdose of it. Too much C-peptide is known to be harmful. Only type 1 people should use an insulin containing C-peptide. Some T1D's still produce some insulin for a period of time after diagnosis. That happens during the 'honeymoon' period with many individuals. Even some Joslin Medalists, T1 for 50+ years, have been found to still produce some insulin. So, there are both T1 and T2 individuals for whom insulin containing C-peptide could prove harmful. Maybe that is the reason any experimentation involving adding C-peptide to insulin was considered inappropriate. I am just guessing, but all of this does make sense to me.

There does not seem to be any present day attempts being made to add C-peptide to insulin, and the attempt to produce an injectable form of C-peptide has failed, for reasons stated. I am not aware that any other attempts are being made to provide us with C-peptide, but I have not given up hope. I am thinking that each individual could be tested and the appropriate amount of C-peptide needed could be determined. Then a prescription could be given that would enable that individual to inject that amount of C-peptide daily, weekly, or for an appropriate time schedule. That may seem far fetched, but I think there has to be a way for us to receive some of this potentially valuable substance.

What are your thoughts?

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